Human gammaherpesvirus 8
| Amiloride | KSHV | Epithelial sodium channel inhibitor | Preclinical | — | Human ion channel | |
| Brincidofovir | KSHV | Viral DNA polymerase inhibitor | Preclinical | — | Viral DNA pol | |
| Camptothecin | KSHV | Topoisomerase I inhibitor | Preclinical | — | Human topoisomerase | |
| Chloroquine | KSHV | Antimalaria agent; chemo/radio sensitizer | Preclinical | — | Human (multiple) | |
| Cidofovir | KSHV | Viral DNA polymerase inhibitor | Preclinical | — | Viral DNA pol | |
| Docosanol | KSHV | Inhibition of fusion | Phase 2 | — | Viral glycoprotein | |
| Famciclovir | KSHV | Viral DNA Polymerase Inhibitor | Approved (other) | JapanRussia | Viral DNA pol | |
| Fiacitabine | KSHV | Inhibits viral DNA synthesis | Preclinical | — | Viral DNA pol | |
| Filociclovir | KSHV | Dual DNA polymerase/kinase inhibitor; Nucleoside analog | Preclinical | — | Viral DNA pol | |
| Foscarnet | KSHV | Pyrophosphate analog DNA polymerase inhibitor | Approved (other) | Japan | Viral DNA pol | |
| Glycyrrhizin | KSHV | — | Preclinical | — | Human TNF | |
| Labyrinthopeptin A1 | KSHV | Interference with viral phospholipid membrane | Preclinical | — | Viral membrane | |
| Labyrinthopeptin A2 | KSHV | viral membrane lipid phosphatidylethanolamine | Preclinical | — | Viral membrane | |
| Metformin | KSHV | AMPK activator | Preclinical | — | Human PTK | |
| Mitoxantrone | KSHV | Topoisomerase II inhibitor | Phase 2 | — | Human topoisomerase | |
| Nelfinavir | KSHV | HIV protease inhibitor | Approved (other) | Japan | Unknown | |
| Novobiocin | KSHV | Bacterial DNA gyrase inhibitor (targeting GyrB) | Preclinical | — | Unknown | |
| Sirolimus | KSHV | IL-2-dependent T-cell proliferation inhibitor | Phase 2 | — | Human PTK | |
| Sorafenib | KSHV | B-Raf; FGFR-1; VEGFR-2 & -3; PDGFR-beta; KIT; and FLT3 inhibitor | Preclinical | — | Human PTK | |
| Valganciclovir | KSHV | Destabilization of DNA | Approved (other) | Japan | Viral DNA pol | |
| Verdinexor | KSHV | Nuclear export inhibitor | Preclinical | — | Human exportin |