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Sorafenib

B-Raf; FGFR-1; VEGFR-2 & -3; PDGFR-beta; KIT; and FLT3 inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
MLDQJTXFUGDVEO-UHFFFAOYSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus10

Human gammaherpesvirus 8
KSHV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
NCT00287495
Chikungunya virus
CHIKV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29981794
Influenza A virus
FLUAV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30883607
Hepacivirus C
HCV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23281732
Enterovirus A
EV-A71
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:24680956
Human alphaherpesvirus 1
HSV-1
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30883607
Hantaan orthohantavirus
HTNV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30883607
Rabies lyssavirus
RABV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29459063
Sindbis virus
SINV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29981794
Indiana vesiculovirus
VSV
Target: Human PTK
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30883607