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Brincidofovir

Viral DNA polymerase inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CCCCCCCCCCCCCCCCOCCCOP(=O)(COC(CN1C=CC(=NC1=O)N)CO)[O-].[Na+]
CRDDLOITBKEPRN-UQIIZPHYSA-M
ClinicalTrials.govPubMed

Clinical Development by Virus13

Human alphaherpesvirus 1
HSV-1
Target: Viral DNA pol
Phase 3
Preclinical
Phase 2unknown
Phase 3
Approved
Phase 2 ref (PMID:28197698) Phase 3 ref (pubmed.ncbi.nlm.nih.gov) PMID:30120866 NCT01610765 NCT01143181
Human polyomavirus 1
BKV
Target: Viral DNA pol
Phase 3
Preclinical
Phase 2unknown
Phase 3
Approved
Phase 2 ref (PMID:25801568) Phase 3 ref (pubmed.ncbi.nlm.nih.gov) NCT01769170
Vaccinia virus
VACV
Target: Viral DNA pol
Phase 3
Preclinical
Phase 2positive
Phase 3negative
Approved
Phase 3 ref (pubmed.ncbi.nlm.nih.gov) PMID:30677427 NCT01143181
Human adenovirus
HAdV
Target: Viral DNA pol
Phase 3
Preclinical
Phase 2positive
Phase 3
Approved
Phase 2 ref (Ref) NCT02087306 NCT01143181 Ref
Human betaherpesvirus 5
CMV
Target: Viral DNA pol
Phase 3
Preclinical
Phase 2positive
Phase 3positive
Approved
Phase 3 ref (pmc.ncbi.nlm.nih.gov) NCT01769170 NCT01143181 NCT00942305
Human betaherpesvirus 6
HHV-6
Target: Viral DNA pol
Phase 3
Preclinical
Phase 2positive
Phase 3
Approved
Phase 2 ref (PMID:32076716) NCT01769170
Human smallpox
Smallpox
Target: DNA polymerase
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDA
Approval ref: AntiviralDb
Human gammaherpesvirus 4
EBV
Target: Viral DNA pol
Phase 3
Preclinical
Phase 2
Phase 3
Approved
NCT01769170
Zaire ebolavirus
EBOV
Target: Viral RNA pol
Phase 2
Preclinical
Phase 2
Phase 3
Approved
PACTR201411000939962 NCT02271347
Primate erythroparvovirus 1
B19V
Target: Viral DNA pol
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30529090
Human polyomavirus 2
JCV
Target: Viral DNA pol
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30677427
Human gammaherpesvirus 8
KSHV
Target: Viral DNA pol
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30677427
Human alphaherpesvirus 3
VZV
Target: Viral DNA pol
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30120866