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Camptothecin

Topoisomerase I inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
VSJKWCGYPAHWDS-FQEVSTJZSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus7

Human gammaherpesvirus 4
EBV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:19494003
Influenza A virus
FLUAV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:4475096
Hepacivirus C
HCV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26045353
Enterovirus A
EV-A71
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:28427827
Human immunodeficiency virus 1
HIV-1
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20110878
Human alphaherpesvirus 1
HSV-1
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20397103
Human gammaherpesvirus 8
KSHV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:22106228