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Mitoxantrone

Topoisomerase II inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
KKZJGLLVHKMTCM-UHFFFAOYSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus8

Human gammaherpesvirus 8
KSHV
Target: Human topoisomerase
Phase 2
Preclinical
Phase 2
Phase 3
Approved
NCT00002259
Zika virus
ZIKV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30791609
Dengue virus
DENV-2
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30791609
Hepacivirus C
HCV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30791609
Human alphaherpesvirus 1
HSV-1
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30791609
Ross River virus
RRV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30791609
Sindbis virus
SINV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30791609
Yellow fever virus
YFV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30791609