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Famciclovir

Viral DNA Polymerase Inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
GGXKWVWZWMLJEH-UHFFFAOYSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus6

Herpes simplex virus (HSV)
HSV
Target: DNA polymerase UL30
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanRussia
Approval ref: AntiviralDbApproval ref (kegg.jp) Approval ref (pmda.go.jp)
Human alphaherpesvirus 3
VZV
Target: DNA polymerase
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanRussia
Approval ref: AntiviralDbApproval ref (kegg.jp) Approval ref (pmda.go.jp) DB00426
Human alphaherpesvirus 1
HSV-1
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) DB00426
Human alphaherpesvirus 2
HSV-2
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) DB00426
Human gammaherpesvirus 8
KSHV
Target: Viral DNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:21837785
Hepatitis B virus
HBV
Target: Viral DNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:10898322