Orthoherpesviridae · Simplexvirus
| Acyclovir | HSV-2 | Viral DNA polymerase inhibitor | FDA approved | FDAJapanChinaRussia | Viral DNA pol | |
| Tenofovir | HSV-2 | Nucleotide analog RT inhibitor | Phase 3 | — | Viral DNA pol | |
| pritelivir | HSV-2 | — | Phase 2 | — | — | |
| Betulinic Acid | HSV-2 | Unknown | Preclinical | — | Unknown | |
| Bleomycin | HSV-2 | Unknown | Preclinical | — | Human LIG1 | |
| Bortezomib | HSV-2 | Proteasome inhibitor (26S subunit) | Preclinical | — | Human proteasome | |
| Brivudine | HSV-2 | Inhibits viral DNA synthesis | Preclinical | — | Viral DNA pol | |
| Cidofovir | HSV-2 | Viral DNA polymerase inhibitor | Phase 2 | — | Viral DNA pol | |
| Docosanol | HSV-2 | Inhibition of fusion | FDA approved | FDA | Viral glycoprotein | |
| Emetine | HSV-2 | — | Preclinical | — | Human ribosome | |
| Famciclovir | HSV-2 | Viral DNA Polymerase Inhibitor | FDA approved | FDAJapanRussia | Viral DNA pol | |
| Fiacitabine | HSV-2 | Inhibits viral DNA synthesis | Preclinical | — | Viral DNA pol | |
| Foscarnet | HSV-2 | Pyrophosphate analog DNA polymerase inhibitor | FDA approved | FDAJapan | Viral DNA pol | |
| Ganciclovir | HSV-2 | Viral RNA polymerase inhibitor | Approved (other) | JapanChina | Viral DNA pol | |
| Idoxuridine | HSV-2 | Inhibits viral DNA synthesis | FDA approved | FDAJapan | Viral DNA pol | |
| Ilaprazole | HSV-2 | Inhibition of Tsg101, prevents viral budding | Preclinical | — | Human vesicular trafficking | |
| Inosine (Inosine pranobex) | HSV-2 | Stimulates cell-mediated immune response | FDA approved | FDA | Viral DNA pol | |
| Kasugamycin | HSV-2 | — | Preclinical | — | Unknown | |
| Labyrinthopeptin A2 | HSV-2 | viral membrane lipid phosphatidylethanolamine | Preclinical | — | Viral membrane | |
| Navitoclax | HSV-2 | Bcl-2/Bcl-xL inhibitor | Preclinical | — | Human BCL2 | |
| Niclosamide | HSV-2 | — | Preclinical | — | Human (multiple) | |
| Obatoclax | HSV-2 | Bcl-2 family inhibitor | Preclinical | — | Human MCL1 | |
| Penciclovir | HSV-2 | Inhibits viral DNA synthesis | FDA approved | FDA | Viral DNA pol | |
| Quercetin | HSV-2 | Inhibition of entry | Preclinical | — | Human (multiple) | |
| Resveratrol | HSV-2 | Multiple | Preclinical | — | Human multiple; Viral transcriptional regulator |