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Bortezomib

Proteasome inhibitor (26S subunit)

2D Structure

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3D Structure

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Chemical Identifiers

B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
GXJABQQUPOEUTA-DOTOQJQBSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus16

Dengue virus
DENV-2
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26565697
Hepatitis B virus
HBV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:19949053
Human orthopneumovirus
RSV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:19931343
Chikungunya virus
CHIKV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:32469886
Eastern equine encephalitis virus
EEEV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25927990
Influenza A virus
FLUAV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20592098
Human alphaherpesvirus 1
HSV-1
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31088925
Human alphaherpesvirus 2
HSV-2
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31088925
Nipah henipavirus
NiV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:21085610
Enterovirus C
PV-1
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:18382670
Rift Valley fever phlebovirus
RVFV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26001632
Dabie bandavirus
SFTSV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31637631
Venezuelan equine encephalitis virus
VEEV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25927990
Indiana vesiculovirus
VSV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20592098
Western equine encephalitis virus
WEEV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25927990
Zika virus
ZIKV
Target: Human proteasome
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27476412