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Navitoclax

Bcl-2/Bcl-xL inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(…
JLYAXFNOILIKPP-KXQOOQHDSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus12

Influenza A virus
FLUAV
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Bunyamwera orthobunyavirus
BUNV
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Influenza B virus
FLUBV
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Hepatitis B virus
HBV
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:28946654
Enterovirus B
ECHOV-6
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Human immunodeficiency virus 1
HIV-1
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
N.A.
Human alphaherpesvirus 1
HSV-1
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Human alphaherpesvirus 2
HSV-2
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:28946654
Measles morbillivirus
MeV
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Sindbis virus
SINV
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23887633
Zika virus
ZIKV
Target: Human BCL2
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:28946654