Orthoherpesviridae · Simplexvirus
| Brincidofovir | HSV-1 | Viral DNA polymerase inhibitor | Phase 3 | — | Viral DNA pol | |
| Vidarabine | HSV-1 | Viral DNA synthesis inhibitor | FDA approved | FDAJapan | Viral DNA pol | |
| Acetylsalicylic acid | HSV-1 | Cyclooxygenase inhibitor | Preclinical | — | Human COX | |
| Acyclovir | HSV-1 | Viral DNA polymerase inhibitor | FDA approved | FDAJapanChinaRussia | Viral DNA pol | |
| Adefovir | HSV-1 | Inhibits viral DNA synthesis | Preclinical | — | Viral RT | |
| Amiloride | HSV-1 | Epithelial sodium channel inhibitor | Preclinical | — | Human ion channel | |
| Amiodarone | HSV-1 | Non-competitive β-adrenergic inhibitor | Preclinical | — | Human (multiple) | |
| Amodiaquine | HSV-1 | Methyltransferase inhibitor | Preclinical | — | Human HNMT | |
| AVN-944 | HSV-1 | IMPDH inhibitor | Preclinical | — | Human IMPDH | |
| Berberine | HSV-1 | AMP-activated protein kinase (AMPK) activator | Preclinical | — | Unknown | |
| Betulinic Acid | HSV-1 | Unknown | Preclinical | — | Unknown | |
| Bortezomib | HSV-1 | Proteasome inhibitor (26S subunit) | Preclinical | — | Human proteasome | |
| Brivudine | HSV-1 | Inhibits viral DNA synthesis | Preclinical | — | Viral DNA pol | |
| Caffeine | HSV-1 | Adenosine-receptor antagonist | Preclinical | — | Viral DNA pol | |
| Camptothecin | HSV-1 | Topoisomerase I inhibitor | Preclinical | — | Human topoisomerase | |
| Cepharanthine | HSV-1 | — | Preclinical | — | Unknown | |
| Cidofovir | HSV-1 | Viral DNA polymerase inhibitor | Phase 2 | — | Viral DNA pol | |
| Didanosine | HSV-1 | Viral DNA chain termination | Approved (other) | Japan | Viral DNA pol | |
| Docosanol | HSV-1 | Inhibition of fusion | FDA approved | FDA | Viral glycoprotein | |
| Eflornithine | HSV-1 | Enzyme-activated; irreversible inhibitor of ornithine decarboxylase | Preclinical | — | Human ODC | |
| Emodin | HSV-1 | — | Preclinical | — | Human (multiple) | |
| Etanercept | HSV-1 | Unknown | Preclinical | — | Human TNF | |
| Famciclovir | HSV-1 | Viral DNA Polymerase Inhibitor | FDA approved | FDAJapanRussia | Viral DNA pol | |
| Fiacitabine | HSV-1 | Inhibits viral DNA synthesis | Preclinical | — | Viral DNA pol | |
| Flavopiridol | HSV-1 | CDK inhibitor | Preclinical | — | Human PTK |