Influenza A virus
| Nitazoxanide | FLUAV | Pyruvate inhibitor | Phase 3 | — | Human pyruvate synthase | |
| Umifenovir | FLUAV | — | FDA approved | FDAChinaRussia | Human (multiple) | |
| Peramivir | FLUAV | Neuraminidase inhibitor | FDA approved | FDAJapan | Neuraminidase | |
| pimodivir | FLUAV | — | Phase 3 | — | — | |
| Acetylsalicylic acid | FLUAV | Cyclooxygenase inhibitor | Preclinical | — | Human COX | |
| Adefovir | FLUAV | Inhibits viral DNA synthesis | Preclinical | — | Viral RT | |
| Amantadine | FLUAV | M2 ion channel blocker; prevents acidification of viral interior, blocking uncoating | FDA approved | FDAJapan | M2 proton channel (Matrix protein 2) | |
| Amitriptyline | FLUAV | Block Viral Entry | Preclinical | — | Human ion channel | |
| Aprotinin | FLUAV | Serine protease inhibitor | Preclinical | — | Human (multiple) | |
| Azacitidine | FLUAV | Nucleoside analog DNA methyl transferase inhibitor | Preclinical | — | Viral RNA pol | |
| Azaribine | FLUAV | Inhibition of Viral Genome Replication | Preclinical | — | Viral RNA pol | |
| Azithromycin | FLUAV | — | Preclinical | — | Human (multiple) | |
| Baloxavir marboxil | FLUAV | Blocks intracellular viral RNA synthesis | FDA approved | FDAJapan | Viral endonuclease | |
| Berberine | FLUAV | AMP-activated protein kinase (AMPK) activator | Preclinical | — | Unknown | |
| Betulinic Acid | FLUAV | Unknown | Preclinical | — | Unknown | |
| Bortezomib | FLUAV | Proteasome inhibitor (26S subunit) | Preclinical | — | Human proteasome | |
| Brequinar | FLUAV | Inhibition of Viral Genome Replication | Preclinical | — | Human DHODH | |
| Caffeine | FLUAV | Adenosine-receptor antagonist | Preclinical | — | Viral RNA pol | |
| Camostat | FLUAV | — | Preclinical | — | Human protease | |
| Camptothecin | FLUAV | Topoisomerase I inhibitor | Preclinical | — | Human topoisomerase | |
| Chloroquine | FLUAV | Antimalaria agent; chemo/radio sensitizer | Phase 2 | — | Human (multiple) | |
| Clarithromycin | FLUAV | Prevent viral entry | Phase 2 | — | Human ion channel | |
| Cyclosporine | FLUAV | Calcineurin inhibitor allows for inhibition of T cell activation | Preclinical | — | Human CYPs | |
| Dapivirine | FLUAV | Non-nucleoside RT inhibitor | Preclinical | — | Unknown | |
| Diltiazem | FLUAV | Viral protease inhibitor | Preclinical | — | Human ion channel |