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Brequinar

DHODH (DHODH) inhibitor · Inhibition of Viral Genome Replication · Dihydroorotate dehydrogenase (DHODH) inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)[O-].[Na+]
PZOHOALJQOFNTB-UHFFFAOYSA-M
ClinicalTrials.govPubMed

Clinical Development by Virus14

Phase 2
Preclinical
Phase 2negative
Phase 3
Approved
NCT04575038
Rubivirus rubellae
RuV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30974126
Dengue virus
DENV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
NCT03760666
Influenza A virus
FLUAV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31941776
Influenza B virus
FLUBV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31941776
Human immunodeficiency virus 1
HIV-1
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
Ref
Argentinian mammarenavirus
JUNV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31302150
Lassa mammarenavirus
LASV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31302150
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31302150
Powassan virus
POWV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20606073
Indiana vesiculovirus
VSV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20606073
West Nile virus
WNV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20606073
Yellow fever virus
YFV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:20606073
Lujo mammarenavirus
LUJV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:34203149