RaDVaC Data Explorer
Antiviral database
Virus Taxonomy
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Nitazoxanide
Pyruvate inhibitor
2D Structure
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3D Structure
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Chemical Identifiers
SMILES:
CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
InChI Key:
YQNQNVDNTFHQSW-UHFFFAOYSA-N
ClinicalTrials.gov
PubMed
Clinical Development by Virus
19
Hepacivirus C
HCV
Target: Human pyruvate synthase
Phase 3
Preclinical
Phase 2
uncertain
Phase 3
Approved
Phase 2 ref (PMID:26974581)
Phase 3 ref (biospace.com)
NCT01770483
Norwalk virus
NoV
Target: Human pyruvate synthase
Phase 3
Preclinical
Phase 2
unknown
Phase 3
Approved
Phase 2 ref (PMID:19442032)
Phase 3 ref (Ref)
NCT03395405
NCT00302640
PMID:30104275
Human adenovirus
HAdV
Target: Human pyruvate synthase
Phase 3
Preclinical
Phase 2
positive
Phase 3
uncertain
Approved
Phase 3 ref (clinicaltrialsregister.eu)
NCT00302640
Influenza A virus
FLUAV
Target: Human pyruvate synthase
Phase 3
Preclinical
Phase 2
positive
Phase 3
positive
Approved
Phase 3 ref (pubmed.ncbi.nlm.nih.gov)
NCT03336619
NCT02612922
Rubivirus rubellae
RuV
Target: Human pyruvate synthase
Phase 3
Preclinical
Phase 2
unknown
Phase 3
Approved
Phase 2 ref (PMID:19442032)
Phase 3 ref (Ref)
NCT00302640
Zaire ebolavirus
EBOV
Target: Human pyruvate synthase
Phase 2
Preclinical
Phase 2
unknown
Phase 3
Approved
NCT03605862
Rotavirus
RoV
Target: Human pyruvate synthase
Phase 3
Preclinical
Phase 2
unknown
Phase 3
Approved
PMID:28974385
NCT00302640
Severe acute respiratory syndrome-related coronavirus
SARS-CoV-2
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
NCT04788407
EV
EV
Target: Human pyruvate synthase
Phase 3
Preclinical
Phase 2
Phase 3
Approved
NCT03605862
Hepatitis B virus
HBV
Target: Human pyruvate synthase
Phase 2
Preclinical
Phase 2
Phase 3
Approved
PMID:21553812
NCT03905655
Human immunodeficiency virus 1
HIV-1
Target: Human pyruvate synthase
Phase 2
Preclinical
Phase 2
Phase 3
Approved
PMID:25303025
NCT01529073
Japanese encephalitis virus
JEV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:24456815
Middle East respiratory syndrome-related coronavirus
MERS-CoV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27095301
Zika virus
ZIKV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:28685770
Chikungunya virus
CHIKV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27742486
Human metapneumovirus
HMPV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
Ref
Measles morbillivirus
MeV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29992955
Human orthopneumovirus
RSV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29992955
Vaccinia virus
VACV
Target: Human pyruvate synthase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29625403