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Cyclosporine

Calcineurin inhibitor; allows for inhibition of T cell activation · Calcineurin inhibitor allows for inhibition of T cell activation

2D Structure

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3D Structure

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Chemical Identifiers

CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(…
PMATZTZNYRCHOR-CGLBZJNRSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus16

Hepacivirus C
HCV
Target: Human CYPs
Phase 3
Preclinical
Phase 2unknown
Phase 3
Approved
Phase 2 ref (PMID:20112171) Phase 3 ref (pubmed.ncbi.nlm.nih.gov) PMID:16382464 NCT00821587
Human immunodeficiency virus 1
HIV-1
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
NCT00979706
Human betaherpesvirus 5
CMV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:22238232 NCT02328963
Preclinical
Preclinical
Phase 2
Phase 3
Approved
NCT04392531
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29772254
Dengue virus
DENV-2
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:19451286
Influenza A virus
FLUAV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:16382464
Human coronavirus 229E
HCoV-229E
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:22046132
Human coronavirus NL63
HCoV-NL63
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:22046132
Rift Valley fever phlebovirus
RVFV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29698664
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:22046132
Vaccinia virus
VACV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:9472618
Indiana vesiculovirus
VSV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:12810862
West Nile virus
WNV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:19451286
Yellow fever virus
YFV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:19451286
Zika virus
ZIKV
Target: Human CYPs
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27476412