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Amantadine

M2 ion channel blocker; prevents acidification of viral interior, blocking uncoating · Viroporin inhibitor; blocks viral ion channel activity

2D Structure

Could not render structureView on PubChem

3D Structure

No structure available on PubChemSearch PubChem

Chemical Identifiers

C1C2CC3CC1CC(C2)(C3)N
DKNWSYNQZKUICI-UHFFFAOYSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus15

Influenza virus
Influenza
Target: M2 proton channel (Matrix protein 2)
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapan
Approval ref: AntiviralDbApproval ref (pmda.go.jp)
Influenza A virus
FLUAV
Target: M2 proton channel (Matrix protein 2)
FDA approved
Preclinical
Phase 2
Phase 3
Approved
FDAJapan
Approval ref (pmda.go.jp) DB00915
Dengue virus
DENV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:27920420
Severe acute respiratory syndrome-related coronavirus
SARS-CoV-2
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:33040252
Hepatitis B virus
HBV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:25039150
Foot-and-mouth disease virus
FMDV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:25946195
Hepatovirus A
HAV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:2167349
Hantaan orthohantavirus
HTNV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:18459839
Argentinian mammarenavirus
JUNV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:8031239
Lassa mammarenavirus
LASV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:2923547
Lymphocytic choriomeningitis mammarenavirus
LCMV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:18619367
Mopeia mammarenavirus
MOPV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:2923547
Cali mammarenavirus
PICV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:2923547
Indiana vesiculovirus
VSV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:2825623
West Nile virus
WNV
Target: Viral ion channel (viroporin)
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (pmda.go.jp) PMID:27014219