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Baloxavir marboxil

Blocks intracellular viral RNA synthesis

2D Structure

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3D Structure

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Chemical Identifiers

COC(=O)OCOC1=C2C(=O)N3CCOCC3N(N2C=CC1=O)C4C5=C(CSC6=CC=CC=C46)C(=C(C=C…
RZVPBGBYGMDSBG-GGAORHGYSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus6

Influenza virus
Influenza
Target: RNA polymerase
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapan
Approval ref: AntiviralDbApproval ref (kegg.jp) Approval ref (pmda.go.jp)
Influenza A virus
FLUAV
Target: Viral endonuclease
FDA approved
Preclinical
Phase 2
Phase 3
Approved
FDAJapan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) DB13997
Influenza B virus
FLUBV
Target: Viral endonuclease
FDA approved
Preclinical
Phase 2
Phase 3
Approved
FDAJapan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) DB13997
Bunyamwera orthobunyavirus
BUNV
Target: Viral endonuclease
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:32766680
Hantaan orthohantavirus
HTNV
Target: Viral endonuclease
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:21680975
La Crosse orthobunyavirus
LACV
Target: Viral endonuclease
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:32766680