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Umifenovir

Inhibits membrane fusion

2D Structure

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3D Structure

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Chemical Identifiers

CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3
KCFYEAOKVJSACF-UHFFFAOYSA-N
PubChemClinicalTrials.govPubMed

Clinical Development by Virus15

Influenza A virus
FLUAV
Target: Human (multiple)
FDA approved
Preclinical
Phase 2positive
Phase 3
Approved
FDAChinaRussia
Phase 2 ref (PMID:32405421) Phase 3 ref (pubmed.ncbi.nlm.nih.gov) PubChem CID:131411 NCT01651663
Influenza B virus
FLUBV
Target: Human (multiple)
FDA approved
Preclinical
Phase 2positive
Phase 3
Approved
FDAChinaRussia
Phase 2 ref (PMID:32405421) Phase 3 ref (pubmed.ncbi.nlm.nih.gov) PubChem CID:131411 NCT01651663
Approved (other)
Preclinical
Phase 2positive
Phase 3negative
Approved
ChinaRussia
Phase 3 ref (pubmed.ncbi.nlm.nih.gov) PMID:33811756 PMID:32283143
Human alphaherpesvirus 2
HSV-2
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30612085
Zaire ebolavirus
EBOV
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30700611
Human alphaherpesvirus 1
HSV-1
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:28890393
Lassa mammarenavirus
LASV
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30700611
Tick-borne encephalitis virus
TBEV
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29642580
West Nile virus
WNV
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29642580
Zika virus
ZIKV
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29895962
Betacoronavirus 1
HCoV-OC43
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:34452529
Human coronavirus 229E
HCoV-229E
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:34452529
Argentinian mammarenavirus
JUNV
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:33468464
Cali mammarenavirus
PICV
Target: Human (multiple)
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:33468464
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:33468464