Togaviridae · Alphavirus
| Amiloride | CHIKV | Epithelial sodium channel inhibitor | Preclinical | — | Human ion channel | |
| Atovaquone | CHIKV | Unknown | Preclinical | — | Human DHODH | |
| Berberine | CHIKV | AMP-activated protein kinase (AMPK) activator | Preclinical | — | Unknown | |
| Betulinic Acid | CHIKV | Unknown | Preclinical | — | Unknown | |
| Bortezomib | CHIKV | Proteasome inhibitor (26S subunit) | Preclinical | — | Human proteasome | |
| Chloroquine | CHIKV | Antimalaria agent; chemo/radio sensitizer | Phase 3 | — | Human (multiple) | |
| Chlorpromazine | CHIKV | Inhibits assembly of clathrin-coated pits at the plasma membrane | Preclinical | — | Human (multiple) | |
| Doxycycline | CHIKV | — | Preclinical | — | Unknown | |
| Eflornithine | CHIKV | Enzyme-activated; irreversible inhibitor of ornithine decarboxylase | Preclinical | — | Human ODC | |
| Eptifibatide | CHIKV | Decreases platelet aggregation | Preclinical | — | Human integrin | |
| Favipiravir | CHIKV | Viral RNA polymerase inhibitor | Approved (other) | Japan | Viral RNA pol | |
| Halofuginone | CHIKV | tRNA synthase inhibitor | Preclinical | — | Human (multiple) | |
| Hydroxychloroquine | CHIKV | Unclear | Preclinical | — | Human (multiple) | |
| Ivermectin | CHIKV | Importin ?/?-mediated nuclear import inhibitor | Preclinical | — | Human importin | |
| Labyrinthopeptin A1 | CHIKV | Interference with viral phospholipid membrane | Preclinical | — | Viral membrane | |
| Labyrinthopeptin A2 | CHIKV | viral membrane lipid phosphatidylethanolamine | Preclinical | — | Viral membrane | |
| Lanatoside C | CHIKV | Increasing the concentration of intracellular calcium | Preclinical | — | Unknown | |
| Luteolin | CHIKV | Unknown | Preclinical | — | Unknown | |
| Merimepodib | CHIKV | IMPDH inhibitor | Preclinical | — | Human IMPDH | |
| Mycophenolic acid | CHIKV | Inosine monophosphate dehydrogenase inhibitor | Preclinical | — | Human IMPDH | |
| N4-Hydroxycytidine | CHIKV | Ribonucleoside analog | Preclinical | — | Viral RNA pol | |
| Nelfinavir | CHIKV | HIV protease inhibitor | Approved (other) | Japan | Unknown | |
| Niclosamide | CHIKV | — | Preclinical | — | Human (multiple) | |
| Nitazoxanide | CHIKV | Pyruvate inhibitor | Preclinical | — | Human pyruvate synthase | |
| Ribavirin | CHIKV | Nucleoside inhibitor Guanosine (ribonucleic) analog | Approved (other) | Japan | Viral RNA pol |