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Ivermectin

Importin ?/?-mediated nuclear import inhibitor · Importin-mediated nuclear import inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)…
SPBDXSGPUHCETR-CVSKBELMSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus12

Dengue virus
DENV
Target: Human importin
Phase 3
Preclinical
Phase 2negative
Phase 3
Approved
Phase 2 ref (PMID:33462580) NCT03432442 NCT02045069 PMID:33462580
Phase 2
Preclinical
Phase 2negative
Phase 3
Approved
Phase 2 ref (PMID:36803992) NCT04739410 PMID:32251768
Chikungunya virus
CHIKV
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26752081
Hendra henipavirus
HENV
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29321677
Human immunodeficiency virus 1
HIV-1
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:22417684
Sindbis virus
SINV
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26752081
Yellow fever virus
YFV
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26752081
Zika virus
ZIKV
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27476412
Semliki Forest virus
SFV
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26752081
Human mastadenovirus C
HAdV-5
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:32641484
Human mastadenovirus B
HAdV-3
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:32641484
Human polyomavirus 1
BKV
Target: Human importin
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25463609