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Ribavirin

Nucleoside inhibitor; Guanosine (ribonucleic) analog · Nucleoside inhibitor Guanosine (ribonucleic) analog

2D Structure

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3D Structure

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Chemical Identifiers

C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
IWUCXVSUMQZMFG-AFCXAGJDSA-N
PubChemDrugBankClinicalTrials.govPubMed

Clinical Development by Virus23

Human orthopneumovirus
RSV
Target: Viral RNA pol
FDA approved
Preclinical
Phase 2negative
Phase 3
Approved
FDAJapanChinaRussia
Phase 2 ref (PMID:38972604) Phase 3 ref (pmc.ncbi.nlm.nih.gov) Approval ref: AntiviralDbApproval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:37542 DB00811 NCT00016081
Hepacivirus C
HCV
Target: NS5A phosphoprotein
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref: AntiviralDbApproval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:37542 DB00811 NCT03069001
Orthohepevirus A
HEV
Target: Viral RNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:37542 NCT01698723
Lassa mammarenavirus
LASV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:28916737 NCT00992693
Rubivirus rubellae
RuV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:26408355
Chikungunya virus
CHIKV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:30354193
Mamastrovirus 1
HAstV-4
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31864069
Mamastrovirus 9
Ast-VA1
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31864069
Human orthorubulavirus 2
HPIV-2
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:25154465
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31302150
Measles morbillivirus
MeV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:30030950
Rabies lyssavirus
RABV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:29459063
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:32020029
Dengue virus
DENV-1
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Dengue virus
DENV-2
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Dengue virus
DENV-4
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Japanese encephalitis virus
JEV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
West Nile virus
WNV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Yellow fever virus
YFV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Zika virus
ZIKV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Usutu virus
USUV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Langat virus
LGTV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009
Wesselsbron virus
WESSV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:12719009