Hepadnaviridae · Orthohepadnavirus
| Tenofovir | HBV | Nucleotide analog RT inhibitor | FDA approved | FDAChinaRussia | Viral RT | |
| Entecavir | HBV | — | FDA approved | FDAJapanChina | DNA polymerase | |
| Telbivudine | HBV | Viral DNA chain termination | FDA approved | FDA | DNA polymerase | AntiviralDbDB1265 |
| Adefovir | HBV | — | FDA approved | FDA | DNA polymerase | AntiviralDb |
| Tenofovir disoproxil fumarate | HBV | — | FDA approved | FDAJapanChina | DNA polymerase | |
| Tenofovir alafenamide | HBV | — | FDA approved | FDAJapanChina | DNA polymerase | |
| Clevudine | HBV | — | Approved (other) | EMA | DNA polymerase | AntiviralDb |
| Besifovir dipivoxil maleate | HBV | — | Approved (other) | South Korea | — | |
| selgantolimod | HBV | — | Phase 2 | — | — | |
| GLS4 | HBV | — | Phase 2 | — | — | |
| Tenofovir disoproxil | HBV | — | FDA approved | FDAJapanChina | — | |
| Adefovir dipivoxil | HBV | Viral DNA chain termination | FDA approved | FDAJapan | Viral RNA pol | |
| Amantadine | HBV | Viroporin inhibitor; blocks viral ion channel activity | Approved (other) | Japan | Viral ion channel (viroporin) | |
| AVN-944 | HBV | IMPDH inhibitor | Preclinical | — | Human IMPDH | |
| Bexarotene | HBV | Unknown | Preclinical | — | Human RAR | |
| Bortezomib | HBV | Proteasome inhibitor (26S subunit) | Preclinical | — | Human proteasome | |
| Dexelvucitabine | HBV | Nucleoside RT inhibitor | Preclinical | — | Viral RT | |
| Elvucitabine | HBV | Nucleoside analog RT Inhibitor | Preclinical | — | Viral RT | |
| Emodin | HBV | — | Preclinical | — | Human (multiple) | |
| Emtricitabine | HBV | viral nucleoside reverse transcritase inhibitor | Approved (other) | JapanRussia | Viral RT | |
| Ezetimibe | HBV | Intestinal cholesterol and related phytosterol absorption inhibitor | Preclinical | — | Human cholesterol transporter | |
| Famciclovir | HBV | Viral DNA Polymerase Inhibitor | Approved (other) | JapanRussia | Viral DNA pol | |
| Fiacitabine | HBV | Inhibits viral DNA synthesis | Preclinical | — | Viral RT | |
| Foscarnet | HBV | Pyrophosphate analog DNA polymerase inhibitor | Approved (other) | Japan | Viral RT | |
| Ganciclovir | HBV | Viral RNA polymerase inhibitor | Approved (other) | JapanChina | Viral RT |