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Ezetimibe

Intestinal cholesterol and related phytosterol absorption inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O
OLNTVTPDXPETLC-XPWALMASSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus7

Hepacivirus C
HCV
Target: Human cholesterol transporter
Phase 3
Preclinical
Phase 2positive
Phase 3uncertain
Approved
Phase 3 ref (Ref) NCT02971033 NCT02768545 NCT04017338
Hepatitis delta virus
HDV
Target: Human cholesterol transporter
Phase 2
Preclinical
Phase 2
Phase 3
Approved
NCT03099278 NCT03099278
Severe acute respiratory syndrome-related coronavirus
SARS-CoV-2
Target: Human cholesterol transporter
Phase 2
Preclinical
Phase 2
Phase 3
Approved
PMID:33083810
Human immunodeficiency virus 1
HIV-1
Target: Human cholesterol transporter
Preclinical
Preclinical
Phase 2
Phase 3
Approved
NCT00099684
Hepatitis B virus
HBV
Target: Human cholesterol transporter
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25034482
Rift Valley fever phlebovirus
RVFV
Target: Human cholesterol transporter
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29698664
Zika virus
ZIKV
Target: Human cholesterol transporter
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29698664