Orthoherpesviridae · Varicellovirus
| Acyclovir | VZV | Viral DNA polymerase inhibitor | FDA approved | FDAJapanChinaRussia | Viral DNA pol | |
| Brivudine | VZV | Inhibits viral DNA synthesis | FDA approved | FDAEMA | DNA polymerase | AntiviralDbDB03312 |
| Vidarabine | VZV | Viral DNA synthesis inhibitor | FDA approved | FDAJapan | DNA polymerase | |
| Famciclovir | VZV | Viral DNA Polymerase Inhibitor | FDA approved | FDAJapanRussia | DNA polymerase | |
| Valaciclovir | VZV | — | FDA approved | FDAJapan | DNA polymerase | |
| sorivudine | VZV | — | Phase 2 | — | — | |
| Tromantadine | VZV | — | Approved (other) | EMA | — | — |
| Brincidofovir | VZV | Viral DNA polymerase inhibitor | Preclinical | — | Viral DNA pol | |
| Caffeine | VZV | Adenosine-receptor antagonist | Preclinical | — | Viral DNA pol | |
| Cidofovir | VZV | Viral DNA polymerase inhibitor | Preclinical | — | Viral DNA pol | |
| Fiacitabine | VZV | Inhibits viral DNA synthesis | Phase 2 | — | Viral DNA pol | |
| Foscarnet | VZV | Pyrophosphate analog DNA polymerase inhibitor | Approved (other) | Japan | Viral DNA pol | |
| Ganciclovir | VZV | Viral RNA polymerase inhibitor | Approved (other) | JapanChina | Viral DNA pol | |
| Homoharringtonine | VZV | Protein translation inhibitor | Preclinical | — | Human ribosome | |
| Inosine (Inosine pranobex) | VZV | Stimulates cell-mediated immune response | Preclinical | — | Viral DNA pol | |
| Seliciclib | VZV | Cyclin-dependent kinase (CDK) inhibitor | Preclinical | — | Human PTK | |
| Valacyclovir | VZV | Inhibits viral DNA synthesis | FDA approved | FDAJapanChinaRussia | Viral DNA pol | |
| Amenamevir | VZV | Helicase-primase inhibitor | Approved (other) | Japan | Viral helicase-primase |