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Valacyclovir

Nucleoside analog DNA polymerase enzyme inhibitor; L-valine ester of aciclovir. · Inhibits viral DNA synthesis

2D Structure

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3D Structure

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Chemical Identifiers

CC(C)C(C(=O)OCCOCN1C=NC2=C1NC(=NC2=O)N)N
HDOVUKNUBWVHOX-QMMMGPOBSA-N
PubChemClinicalTrials.govPubMed

Clinical Development by Virus7

Human betaherpesvirus 5
CMV
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:135398741
Human gammaherpesvirus 4
EBV
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:135398741
Hepatitis B virus
HBV
Target: Viral RT
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:135398741
Human alphaherpesvirus 1
HSV-1
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) DB00577
Human alphaherpesvirus 2
HSV-2
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:135398741 DB00577
Human alphaherpesvirus 3
VZV
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChinaRussia
Approval ref (kegg.jp) Approval ref (pmda.go.jp) DB00577
Hepacivirus C
HCV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) NCT01453075