Zika virus
| Acetylsalicylic acid | ZIKV | Cyclooxygenase inhibitor | Preclinical | — | Human COX | |
| Amodiaquine | ZIKV | Methyltransferase inhibitor | Preclinical | — | Human HNMT | |
| Anisomycin | ZIKV | DNA synthesis inhibitor | Preclinical | — | Human ribosome | |
| Atovaquone | ZIKV | Unknown | Preclinical | — | Human DHODH | |
| Azaribine | ZIKV | Inhibition of Viral Genome Replication | Preclinical | — | Viral RNA pol | |
| Azauridine | ZIKV | Nucleoside analog | Preclinical | — | Viral RNA pol | |
| Azithromycin | ZIKV | — | Preclinical | — | Human (multiple) | |
| Berberine | ZIKV | AMP-activated protein kinase (AMPK) activator | Preclinical | — | Unknown | |
| Betulinic Acid | ZIKV | Unknown | Preclinical | — | Unknown | |
| Bithionol | ZIKV | Uncoupler of oxidative phosphorylation | Preclinical | — | Unknown | |
| Bortezomib | ZIKV | Proteasome inhibitor (26S subunit) | Preclinical | — | Human proteasome | |
| Chloroquine | ZIKV | Antimalaria agent; chemo/radio sensitizer | Preclinical | — | Human (multiple) | |
| Chlorpromazine | ZIKV | Inhibits assembly of clathrin-coated pits at the plasma membrane | Preclinical | — | Human (multiple) | |
| Clofazimine | ZIKV | Non-nucleoside RT inhibitor | Preclinical | — | Viral RNA pol | |
| Clotrimazole | ZIKV | Block Viral Entry (KCa3.1 antagonist) | Preclinical | — | Human cytochrome P450 | |
| CR-1-31-B | ZIKV | Prevents mRNA translation | Preclinical | — | Human ATPase | |
| Cucurbit[7]uril | ZIKV | Competitive binding of polyamines | Preclinical | — | Human polyamines | |
| Cyclosporine | ZIKV | Calcineurin inhibitor; allows for inhibition of T cell activation | Preclinical | — | Human CYPs | |
| Dalbavancin | ZIKV | — | Preclinical | — | Unknown | |
| Dyphillin | ZIKV | vacuolar ATPase inhibitors | Preclinical | — | Human vATPase | |
| Efavirenz | ZIKV | Inhibition of viral RT | Approved (other) | JapanRussia | Viral RNA pol | |
| Eflornithine | ZIKV | Enzyme-activated; irreversible inhibitor of ornithine decarboxylase | Preclinical | — | Human ODC | |
| Emetine | ZIKV | — | Preclinical | — | Human ribosome | |
| Emodin | ZIKV | — | Preclinical | — | Human (multiple) | |
| Enoxacin | ZIKV | DNA Topoisomerase II inhibitor | Preclinical | — | Human topoisomerase |