Coronaviridae · Betacoronavirus
| Lopinavir | MERS-CoV | HIV protease inhibitor | Approved (other) | Japan | Viral protease | |
| Alisporivir | MERS-CoV | — | Preclinical | — | Human CYPs | |
| Amodiaquine | MERS-CoV | Methyltransferase inhibitor | Preclinical | — | Human HNMT | |
| Anisomycin | MERS-CoV | DNA synthesis inhibitor | Preclinical | — | Human ribosome | |
| Benztropine | MERS-CoV | Selective inhibition of dopamine transporters but it also presents affinity for histamine and muscarine receptors | Preclinical | — | Human CHRM1 | |
| Boceprevir | MERS-CoV | NS3/4a protease inhibitor | Preclinical | — | Viral protease | |
| Camostat | MERS-CoV | — | Preclinical | — | Human protease | |
| Chloroquine | MERS-CoV | Antimalaria agentchemo/radio sensitizer | Preclinical | — | Human (multiple) | |
| Chlorpromazine | MERS-CoV | Inhibits assembly of clathrin-coated pits at the plasma membrane | Preclinical | — | Human (multiple) | |
| Clomipramine | MERS-CoV | — | Preclinical | — | Human (multiple) | |
| CR-1-31-B | MERS-CoV | Prevents mRNA translation | Preclinical | — | Human ATPase | |
| Cyclosporine | MERS-CoV | Calcineurin inhibitor allows for inhibition of T cell activation | Preclinical | — | Human CYPs | |
| Dalbavancin | MERS-CoV | — | Preclinical | — | Unknown | |
| Dasatinib | MERS-CoV | Abl; Src; Kit; EphR... Inhibitor | Preclinical | — | Human PTK | |
| Eflornithine | MERS-CoV | Enzyme-activated; irreversible inhibitor of ornithine decarboxylase | Preclinical | — | Human ODC | |
| Emetine | MERS-CoV | — | Preclinical | — | Human ribosome | |
| Fluphenazine | MERS-CoV | Prevent viral entry | Preclinical | — | Human ion channel | |
| Galidesivir | MERS-CoV | RNA-dependent RNA polymerase (RdRp) inhibitor | Preclinical | — | Viral RNA pol | |
| Gemcitabine | MERS-CoV | Antimetabolite; Nucleoside analog | Preclinical | — | Viral RNA pol | |
| GS-441524 | MERS-CoV | nucleoside analog | Preclinical | — | Viral RNA pol | |
| Hexachlorophene | MERS-CoV | — | Preclinical | — | Unknown | |
| Homoharringtonine | MERS-CoV | Protein translation inhibitor | Preclinical | — | Human ribosome | |
| Hydroxychloroquine | MERS-CoV | Unclear | Preclinical | — | Human (multiple) | |
| Imatinib | MERS-CoV | Abl; Kit; PDGFRB inhibitor | Preclinical | — | Human PTK | |
| Mefloquine | MERS-CoV | — | Preclinical | — | Human (multiple) |