Coronaviridae · Alphacoronavirus
| Azauridine | HCoV-NL63 | Nucleoside analog | Preclinical | — | Viral RNA pol | |
| Boceprevir | HCoV-NL63 | NS3/4a protease inhibitor | Preclinical | — | Viral protease | |
| Cyclosporine | HCoV-NL63 | Calcineurin inhibitor; allows for inhibition of T cell activation | Preclinical | — | Human CYPs | |
| Emetine | HCoV-NL63 | — | Preclinical | — | Human ribosome | |
| Monensin | HCoV-NL63 | — | Preclinical | — | Unknown | |
| Mycophenolic acid | HCoV-NL63 | Inosine monophosphate dehydrogenase inhibitor | Preclinical | — | Human IMPDH | |
| N4-Hydroxycytidine | HCoV-NL63 | Ribonucleoside analog | Preclinical | — | Viral RNA pol | |
| Nafamostat | HCoV-NL63 | Synthetic serine protease inhibitor | Preclinical | — | Human protease |