Coronaviridae · Betacoronavirus
| Boceprevir | HCoV-OC43 | NS3/4a protease inhibitor | Preclinical | — | Viral protease | |
| Cepharanthine | HCoV-OC43 | — | Preclinical | — | Unknown | |
| Chloroquine | HCoV-OC43 | Antimalaria agent; chemo/radio sensitizer | Preclinical | — | Human (multiple) | |
| Emetine | HCoV-OC43 | — | Preclinical | — | Human ribosome | |
| Memantine | HCoV-OC43 | N-methyl-D-aspartate glutamate receptor antagonist | Preclinical | — | Human ion channel | |
| Monensin | HCoV-OC43 | — | Preclinical | — | Unknown | |
| Mycophenolic acid | HCoV-OC43 | Inosine monophosphate dehydrogenase inhibitor | Preclinical | — | Human IMPDH | |
| Remdesivir | HCoV-OC43 | Viral RNA polymerase inhibitor | Approved (other) | Japan | Viral RNA pol | |
| Thapsigargin | HCoV-OC43 | Induces host innate immune response | Preclinical | — | Human ion channel | |
| Umifenovir | HCoV-OC43 | Inhibits membrane fusion | Preclinical | — | Human (multiple) |