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Silvestrol

RNA helicase inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

COC1C(OC(CO1)C(CO)O)OC2=CC3=C(C(=C2)OC)C4(C(C(C(C4(O3)C5=CC=C(C=C5)OC)…
GVKXFVCXBFGBCD-QKDMMWSPSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus12

Orthohepevirus A
HEV
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30036559
Lassa mammarenavirus
LASV
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31931103
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31931103
Chikungunya virus
CHIKV
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30380742
Zaire ebolavirus
EBOV
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27864075
Influenza A virus
FLUAV
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29258238
Human coronavirus 229E
HCoV-229E
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29258862
Rhinovirus A
HRV-A1
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29258862
Enterovirus C
PV-1
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29258862
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29258862
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:33422611
Zika virus
ZIKV
Target: Human EIF4A
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29584632