Orthohepevirus A
| Remdesivir | HEV | Viral RNA polymerase inhibitor | Approved (other) | Japan | Viral RNA pol | |
| Ribavirin | HEV | Nucleoside inhibitor; Guanosine (ribonucleic) analog | FDA approved | FDAJapanChinaRussia | Viral RNA pol | |
| Silvestrol | HEV | RNA helicase inhibitor | Preclinical | — | Human EIF4A | |
| Sofosbuvir | HEV | Nucleotide analog inhibitor of HCV NS5B RNA-dependent RNA polymerase | Approved (other) | JapanChina | Viral RNA pol |