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Sofosbuvir

Nucleotide analog inhibitor of HCV NS5B RNA-dependent RNA polymerase

2D Structure

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3D Structure

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Chemical Identifiers

CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
TTZHDVOVKQGIBA-IQWMDFIBSA-N
PubChemDrugBankClinicalTrials.govPubMed

Clinical Development by Virus8

Hepacivirus C
HCV
Target: Viral RNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapanChina
Phase 3 ref (Ref) Approval ref: AntiviralDbApproval ref (kegg.jp) Approval ref (pmda.go.jp) PubChem CID:45375808 DB08934 NCT03069001
Approved (other)
Preclinical
Phase 2negative
Phase 3
Approved
JapanChina
Phase 2 ref (PMID:36908503) Phase 3 ref (pubmed.ncbi.nlm.nih.gov) Approval ref (kegg.jp) Approval ref (pmda.go.jp) NCT04460443
Zika virus
ZIKV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChina
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:27902933
Chikungunya virus
CHIKV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChina
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:30455237
Dengue virus
DENV-2
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChina
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:28834304
Hepatovirus A
HAV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChina
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:29653132
Orthohepevirus A
HEV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChina
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31362004
Yellow fever virus
YFV
Target: Viral RNA pol
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
JapanChina
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31594756