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Nafamostat

Synthetic serine protease inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N
MQQNFDZXWVTQEH-UHFFFAOYSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus7

Phase 3
Preclinical
Phase 2negative
Phase 3
Approved
Phase 2 ref (PMID:34723164) Phase 3 ref (pubmed.ncbi.nlm.nih.gov) NCT04352400
Human coronavirus 229E
HCoV-229E
Target: Human protease
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:34541574
Human coronavirus NL63
HCoV-NL63
Target: Human protease
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:34541574
Zaire ebolavirus
EBOV
Target: Human protease
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26346967
Influenza A virus
FLUAV
Target: Human protease
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:1510439
Influenza B virus
FLUBV
Target: Human protease
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:1510439
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27550352