Enterovirus B
| Amiloride | CVB-3 | Epithelial sodium channel inhibitor | Preclinical | — | Human ion channel | |
| Berberine | CVB-3 | AMP-activated protein kinase (AMPK) activator | Preclinical | — | Unknown | |
| Cucurbit[7]uril | CVB-3 | Competitive binding of polyamines | Preclinical | — | Human polyamines | |
| Dibucaine | CVB-3 | — | Preclinical | — | Human (multiple) | |
| Eflornithine | CVB-3 | Enzyme-activated; irreversible inhibitor of ornithine decarboxylase | Preclinical | — | Human ODC | |
| Emodin | CVB-3 | — | Preclinical | — | Human (multiple) | |
| Fluoxetine | CVB-3 | Selective serotonin reuptake inhibitor | Preclinical | — | Viral ATPase/helicase | |
| Formoterol | CVB-3 | — | Preclinical | — | Unknown | |
| Gemcitabine | CVB-3 | Antimetabolite; Nucleoside analog | Preclinical | — | Viral RNA pol | |
| Itraconazole | CVB-3 | Inhibition of OSBP and ORP4; Inhibition of viral organelle formation | Preclinical | — | Human lipid transfer protein | |
| Lovastatin | CVB-3 | HMG-CoA reductase inhibitor | Preclinical | — | Human HMGCR | |
| Metformin | CVB-3 | AMPK activator | Preclinical | — | Human PTK | |
| Pentosan polysulfate | CVB-3 | — | Preclinical | — | Human FGF | |
| Pirlindole | CVB-3 | — | Preclinical | — | Viral ATPase/helicase | |
| Valproic Acid | CVB-3 | HDAC inhibitor | Preclinical | — | Human HDAC |