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Itraconazole

Antifungal; hedgehog signaling inhibitor · Inhibition of OSBP and ORP4; Inhibition of viral organelle formation

2D Structure

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3D Structure

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Chemical Identifiers

CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN…
VHVPQPYKVGDNFY-ZPGVKDDISA-N
ClinicalTrials.govPubMed

Clinical Development by Virus12

Influenza A virus
FLUAV
Target: Unknown
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30866762
Rhinovirus A
HRV-A1B
Target: Human lipid transfer protein
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26976677
Dengue virus
DENV-2
Target: Human lipid transfer protein
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29981375
Enterovirus B
ECHOV-30
Target: Unknown
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29164043
Enterovirus A
EV-A71
Target: Human lipid transfer protein
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25640182
Enterovirus B
CVB-3
Target: Human lipid transfer protein
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25640182
Rhinovirus B
HRV-B14
Target: Human lipid transfer protein
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25640182
Cardiovirus A
EMCV
Target: Human lipid transfer protein
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25640182
Cardiovirus D
SAFV
Target: Human lipid transfer protein
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25640182
Human metapneumovirus
HMPV
Target: Unknown
Preclinical
Preclinical
Phase 2
Phase 3
Approved
Ref
Parechovirus A
HPEV-3
Target: Unknown
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29155163
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:33752127