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Lovastatin

HMG-CoA reductase inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
PCZOHLXUXFIOCF-BXMDZJJMSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus7

Dengue virus
DENV-2
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:24586275
Human orthopneumovirus
RSV
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:11257039
Enterovirus B
CVB-3
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:24316867
Zaire ebolavirus
EBOV
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29717011
Human respirovirus 1
HPIV-1
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27915128
Rotavirus A
RoV-SA11
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:19030953
Zika virus
ZIKV
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31391514