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Simvastatin

HMG CoA reductase inhibitor

2D Structure

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3D Structure

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Chemical Identifiers

CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
RYMZZMVNJRMUDD-HGQWONQESA-N
ClinicalTrials.govPubMed

Clinical Development by Virus7

Hepacivirus C
HCV
Target: Human HMGCR
Phase 2
Preclinical
Phase 2
Phase 3
Approved
NCT03490097
Hepatitis B virus
HBV
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27779671 NCT00994773
Human betaherpesvirus 5
CMV
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:24976258
Dengue virus
DENV-2
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27431377
Influenza A virus
FLUAV
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:25882623
Enterovirus C
PV-1
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:16824485
Zika virus
ZIKV
Target: Human HMGCR
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:31391514