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Trifluridine

Antimetabolite; Nucleoside analog

2D Structure

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3D Structure

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Chemical Identifiers

C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
VSQQQLOSPVPRAZ-RRKCRQDMSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus7

Herpes simplex virus (HSV)
HSV
Target: DNA polymerase UL30
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDA
Approval ref: AntiviralDb
Human alphaherpesvirus 1
HSV-1
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDA
DB00432
Human alphaherpesvirus 2
HSV-2
Target: Viral DNA pol
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDA
DB00432
Vaccinia virus
VACV
Target: Viral DNA pol
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:21278209
Human mastadenovirus D
HAdV-8
Target: Viral DNA pol
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:99133
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:99133
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:99133