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Topotecan

Topoisomerase I inhibitor. Camptothecin analog

2D Structure

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3D Structure

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Chemical Identifiers

CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
UCFGDBYHRUNTLO-QHCPKHFHSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus7

Human immunodeficiency virus 1
HIV-1
Target: Human topoisomerase
Phase 2
Preclinical
Phase 2
Phase 3
Approved
PMID:9145855 NCT00002395
Zaire ebolavirus
EBOV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27127234
Severe acute respiratory syndrome-related coronavirus
SARS-CoV-2
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:33836156
Dengue virus
DENV-2
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:24727241
Influenza A virus
FLUAV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:27127234
Hepacivirus C
HCV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:23529728
Human polyomavirus 2
JCV
Target: Human topoisomerase
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26935240