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Simeprevir

Recovers host IFN signaling

2D Structure

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3D Structure

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Chemical Identifiers

CC1=C(C=CC2=C1N=C(C=C2OC3CC4C(C3)C(=O)N(CCCCC=CC5CC5(NC4=O)C(=O)NS(=O)…
JTZZSQYMACOLNN-VDWJNHBNSA-N
DrugBankClinicalTrials.govPubMed

Clinical Development by Virus5

Hepacivirus C
HCV
Target: NS3/4A protease
FDA approved
Preclinical
Phase 2positive
Phase 3positive
Approved
FDAJapan
Approval ref: AntiviralDbApproval ref (kegg.jp) Approval ref (pmda.go.jp) DB06290
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:32873185
Enterovirus A
EV-A71
Target: Viral protease
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31563599
Human alphaherpesvirus 1
HSV-1
Target: Viral protease
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31563599
Zika virus
ZIKV
Target: Viral protease
Approved (other)
Preclinical
Phase 2
Phase 3
Approved
Japan
Approval ref (kegg.jp) Approval ref (pmda.go.jp) PMID:31563599