RaDVaC Data Explorer
Antiviral database
Virus Taxonomy
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Leflunomide
Pyrimidine synthesis inhibitor
2D Structure
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3D Structure
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Chemical Identifiers
SMILES:
CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
InChI Key:
VHOGYURTWQBHIL-UHFFFAOYSA-N
ClinicalTrials.gov
PubMed
Clinical Development by Virus
7
Severe acute respiratory syndrome-related coronavirus
SARS-CoV-2
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
NCT04361214
Human gammaherpesvirus 4
EBV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:28574826
Rubivirus rubellae
RuV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:30974126
Human polyomavirus 1
BKV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:22461534
Human betaherpesvirus 5
CMV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:26652481
Human alphaherpesvirus 1
HSV-1
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:11211189
Argentinian mammarenavirus
JUNV
Target: Human DHODH
Preclinical
Preclinical
Phase 2
Phase 3
Approved
PMID:29315647