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Bulevirtide

Entry inhibitor; pre-S1 lipopeptide blocking NTCP-mediated hepatocyte entry

2D Structure

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3D Structure

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Chemical Identifiers

CCCCCCCCCCCCCC(=O)NCC(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)…
WQNDXLHKAMIGEX-WOAPPVHJSA-N
ClinicalTrials.govPubMed

Clinical Development by Virus2

Hepatitis delta virus
HDV
Target: sodium taurocholate cotransporting polypeptide receptor
Approved (other)
Preclinical
Phase 2positive
Phase 3positive
Approved
EMA
Phase 3 ref (gilead.com)
Hepatitis B virus
HBV
Target: NTCP (sodium taurocholate cotransporting polypeptide)
Phase 2
Preclinical
Phase 2negative
Phase 3
Approved
NCT02881008 DB15248